HtrA , LexA and LA

The Protein Data Bank (PDB) is a repository for the 3-D structural data of large biological molecules, such as proteins and nucleic acids.The PDB is a key resource in areas of structural biology, such as structural genomics. Most major scientific journals, and some funding agencies, such as the NIH in the USA, now require scientists to submit their structure data to the PDB. For example,HtrA , LexA and LA molecules.

What is HtrA??

Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene.

This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.

MOLECULAR DESCRIPTION;

Classification:	Hydrolase/hydrolase Activator
Structure Weight:	36714.60

Molecule:	Protease degS
Polymer:	1	Type:	polypeptide(L)
Chains:	A
EC#:	3.4.21.-
Mutation:	H198P,D320A
Molecule:	YQF peptide
Polymer:	2	Type:	polypeptide(L)
Chains:	B

WHAT IS LexA??

Repressor LexA or LexA is a repressor enzyme that represses SOS response genes coding for DNA polymerases required for repairing DNA damage. LexA is intimately linked to RecA in the biochemical cycle of DNA damage and repair. RecA binds to DNA-bound LexA causing LexA to cleave itself in a process called autoproteolysis.

MOLECULAR DESCRIPTION;

Classification:	Transcription Regulator
Structure Weight:	10723.30

Molecule:	SOS-response transcriptional repressor, LexA
Polymer:	1	Type:	polypeptide(L)
Chains:	A
Fragment:	sequence database residues 1-86

WHAT IS LA??

Structure keywords;

Keywords = VIRAL PROTEIN

Text = Viral Protein , SIPHOVIRIDAE , LACTOCOCCUS LACTIS.

MOLECULAR DESCRIPTION;

Classification:	Viral Protein
Structure Weight:	848612.27

Molecule:	ORF16
Polymer:	1	Type:	polypeptide(L)
Chains:	0, Y, Z
Molecule:	PUTATIVE RECEPTOR BINDING PROTEIN
Polymer:	2	Type:	polypeptide(L)
Chains:	A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Fragment:	RESIDUES 2-264
Molecule:	ORF15
Polymer:	3	Type:	polypeptide(L)
Chains:	S, T, U, V, W, X